Fig. 1: Psilocybin-induced changes in neural activity are dependent on 5-HT1BR.
From: The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
(A) Heatmap shows log-transformed counts of c-Fos+ cells for individual mice (columns) across brain regions (rows) for control and 5-HT1BR knockout (KO) mice treated with saline or psilocybin. White squares indicate missing data points. (B) Group means of c-Fos+ cells in six representative brain regions following psilocybin or saline treatment. (C) Percent change in c-Fos+ cells following psilocybin administration is shown in three diagrams of coronal sections of the brain (at bregma +1.94 mm, +0.98 mm, and -2.18 mm) in control (left hemisphere of each diagram) and 5-HT1BR knockout (right hemisphere of each diagram) mice. Psilocybin leads to both increases (shown in red) and decreases (blue) in c-Fos+ cell counts, with notable differences between genotypes, calculated as relative changes in c-Fos expression compared to saline-injected controls, with increases colored as red if they were greater than 200%. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. ILA: infralimbic cortex, PL: prelimbic cortex; ORB: orbitofrontal cortex, ACA: anterior cingulate cortex, CLA: claustrum, ISO: isocortex, COA: cortical amygdala, BLA: basolateral amygdala, BMA: basomedial amygdala, CEA: central amygdala, LA: lateral amygdala, MEA: medial amygdala, PA: posterior amygdala nucleus, BST: bed nucleus of the stria terminalis, LS: lateral septum, TH: thalamus, HY: hypothalamus, ACB: nucleus accumbens, CP: caudate putamen, STR: dorsal striatum, GP: globus pallidus, PAL: pallidum, OT: olfactory tubercle, OLF: olfactory areas, PIR: piriform cortex, EP: endopiriform nucleus, ENT: entorhinal area, dHIP: dorsal hippocampus, vHIP: ventral hippocampus, MB: midbrain.
