Fig. 3: 5-HT1BR is required for behavioral effects of psilocybin in female mice.
From: The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
(A) Experimental timeline is shown for studies testing the post-acute behavioral effects of psilocybin. (B) Gustometer data shows the number of licks in females across 6 concentrations of sucrose in female control and 5-HT1BR KO mice, following chronic cort with saline or psilocybin treatment, and for the no stress control condition. (C) Inset shows the number of licks at the 10% sucrose concentration in females. (D) Kaplan-Meier survival curves represent the cumulative proportion of females eating over time in the NSF for controls (shades of black) and 5-HT1BR KOs (shades of pink). Inset shows individual data points and average group latency to eat. (E) Open arm entries are shown for females in the EPM for controls and KOs over the three treatment groups. (F) Gustometer data shows the number of licks in males across 6 concentrations of sucrose in female control and 5-HT1BR KO mice, following chronic cort with saline or psilocybin treatment, and for the no stress control condition. (G) Inset shows the number of licks at the 10% sucrose concentration in males. (H) Kaplan-Meier survival curves represent the cumulative proportion of males eating over time in the NSF for controls (shades of black) and 5-HT1BR KOs (shades of pink). Inset shows individual data points and average group latency to eat. (I) Open arm entries are shown for males in the EPM for controls and KOs over the three treatment groups. Data points on bar graphs represent individual mice and group averages are shown as mean ± SEM. *p < 0.05, **p < 0.005, ***p < 0.001.
