Fig. 5: The effects of Psilocybin on behavior in a behavioral despair model are mediated by 5-HT1BR expression in both male and female mice.
From: The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
(A) Experimental timeline is shown for testing the post-acute behavioral effects of psilocybin following forced swim stress exposure. (B) Gustometer data shows the number of licks across 6 concentrations of sucrose in control and 5-HT1BR KO mice, following forced swim stress with saline or psilocybin treatment, and for the no stress control condition. (C) The number of licks at the 10% sucrose concentration is shown for control and 5-HT1BR KO mice in the three treatment conditions. (D) Open arm entries are shown in the EPM for both sexes in control and 5-HT1BR KO mice in three treatment groups. (E) Kaplan-Meier survival curves represent the cumulative proportion of mice eating over time in the NSF for controls (shades of black) and 5-HT1BR KOs (shades of yellow). Inset shows individual data points and average group latency to eat. Data points on bar graphs represent individual mice, with females colored pink and males colored blue. Group averages are shown as mean ± SEM. *p < 0.05, **p < 0.005, ***p < 0.001.
