Fig. 6: 5-HT1BR expression influences select neural circuits influenced by psilocybin.
From: The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
(A) The difference correlation matrix shows psilocybin-induced alterations in functional connectivity between control (lower triangle) and 5-HT1BR KO mice (upper triangle). The matrix represents the pairwise correlation differences across 30 regions, illustrating different cross-network synchrony patterns between the two genotypes, with control mice exhibiting more correlated activity following psilocybin than 5-HT1BR KO mice do. (B) Circular network plot highlighting psilocybin-responsive connections most influenced by 5-HT1BR expression. Significant changes in correlated activity were observed across and between the amygdala, basal forebrain, hippocampal formation, and olfactory regions. The CEA, MEA, GP, OT, dHIP, CLA, STR, PAL, ISO, and BLA structures contributed most significantly to the network. Grey edges represent all possible connections in the network. Colored edges indicate all significant (p < 0.001) connections identified in the network.
