Fig. 2: MDD-specific lncRNA biotyping based on transcript distribution and karyotype. | Molecular Psychiatry

Fig. 2: MDD-specific lncRNA biotyping based on transcript distribution and karyotype.

From: Aberrant expression of long non-coding RNAs and their regulatory role in chromatin-mediated gene expression changes in the prefrontal cortex of major depressive disorder subjects

Fig. 2

A Pie chart illustrates the transcriptome-wide distribution of five distinct classes of long non-coding RNAs, identified through expression microarray data in the MDD brain. Each segment of the pie plot represents the total number of lncRNAs identified in their respective classes. B MA plots based on expression values of lncRNAs in MDD subjects demonstrating their respective transcriptional origin in the genome. The expression data identified a large proportion of expressed lncRNAs, which were assigned under two broad categories, i.e., natural antisense and intronic antisense. However, based on the expression data, they were also largely classified into three different categories, including exonic, intergenic, and intronic regions. C Top 21 differentially expressed lncRNAs with ≥1.2-fold expression upregulation in MDD brain. The table also demonstrates the biotype of individual lncRNAs, which was found to be significantly upregulated in the MDD group compared to the control group. D Phenogram displaying the chromosome-wise mapping of the top 21 significantly upregulated lncRNAs in MDD. The lncRNAs are labeled on individual chromosomes, with color annotations indicating their respective biotypes.

Back to article page