Fig. 4: Nonparametric testing of the correlation distribution within functional amygdala clusters.
Voxel-wise correlations between right-amygdala BOLD and Amyg-EFP signals (during passive movie viewing) were calculated along a sliding window of the run time-course and averaged across windows. To generate the null distribution the same procedure was repeated 100 times with shuffled data. (A) Results obtained from four example participants. Left panel presents coronal anatomical views of the right amygdala (dotted outline), highlighting functional salience-related (orange) and non-salience (blue) clusters, defined individually by high or low coactivation with a salience network seed in a separate task. The middle and right panels present the null correlation distribution (gray) and real correlation distribution (x100 for visualization) in the salience-related amygdala cluster (orange) and non-salience amygdala cluster (blue), per participant. Colored dashed lines denote the median of the real distribution, and gray dashed lines denote the 95th percentile of the null distribution (chance level). Above-chance participants were determined by a real-distribution median higher than the 95th percentile of the null distribution. (B) Percentage of above-chance participants (as defined above) in each functional amygdala subregion, in the test group (left) and replication (right), for correlations tested along a 30-TR sliding window. (C) Percentage of above-chance participants (as defined above) in each of the functional amygdala subregions for sliding-window sizes ranging between 10 and 50 TR.
