Table 1 AMP-AD coexpression modules and cross-species screen results.
module | modifiers % (n, tau / Aß / both) | pathway(s) | Selected gene drivers |
|---|---|---|---|
PHGbrown | 53.8 (5/4/5) | synapse organization | GRIN2B, FRMPD4, RBFOX1, RAB6B, ATP6V1C1 |
TCXgreen | 51.6 (5/6/5) | synaptic signaling, plasticity, | SYT12, NSF, PPEF1, HECW1, PCSK2 |
DLPFCblue | 50.0 (4/5/2) | immune response, exocytosis, | ANO6, ARHGEF6, MSN, STOM, TMED10 |
PHGturquoise | 50.0 (4/4/1) | immune response, exocytosis | ITPKB, TAGLN2, CHST6, GEM, PLXDC2 |
PHGyellow | 50.0 (2/3/3) | metabolic process | NDRG2, RANBP3L, NFIA, SPON1, PARD3B |
STGturquoise | 48.3 (4/7/3) | protein folding | STIP1, TRPC1, HSPA4, HSPH1, FKBP4 |
FPblue | 47.8 (1/5/5) | myelination, gliogenesis | DAAM2, SLC6A12, TRPC1, COL4A5, TMTC2 |
FPturquoise | 50 (3/4/1) | immune response, phagocytosis | ITPKB, TAGLN2, CHST6, ANO6, PLXDC2 |
STGblue | 47.1 (2/5/1) | immune response | ANO6, ARHGEF6, MSN, HCK, SASH3 |
TCXyellow | 47.4 (4/2/3) | sphingolipids, myelination, | DEK, STAG1, NDE1, SMC1A, PLPP1 |
IFGturquoise | 44.4 (3/3/2) | immune response, tumor necrosis factor | ITPKB, TAGLN2, CHST6, LCP1, PLXDC2 |
CBEturquoise | 43.5 (3/4/3) | phagocytosis | SASH1, STOM, PTPRC, YAP1 |
DLPFCyellow | 43.2 (7/5/4) | synapse organization | NMNAT2, FAXC, GABRB3, ATRNL1, GAD1 |
IFGyellow | 42.1 (1/3/4) | cell adhesion | PLPP3, ACBD7, NDRG2, GEM, RANBP3L |
DLPFCturquoise | 41.9 (2/10/1) | protein folding | ANO6, ARHGEF6, HCK, STOM |
DLPFCbrown | 38.9 (2/2/3) | sphingolipids, myelination, | CORO6, CHORDC1, COQ4, ALG13, TARBP1 |
FPyellow | 39.6 (7/8/6) | synaptic vesicle cycle | YPEL4, LAMP5, NMNAT2, PRICKLE1, RXFP1 |
STGbrown | 39.5 (6/7/4) | synaptic vesicle cycle, synapse organization | OXR1, CDK14, NAPB, BTBD11, TASP1 |
TCXturquoise | 38.5 (0/4/1) | immune response, exocytosis | A4GALT, HCK, SASH3, ARPC1B, TAGLN2 |
PHGgreen | 38.1 (3/3/2) | cholesterol, myelination | ANLN, NPC1, PHF3, TMCC3, ST18 |
CBEyellow | 39.1 (5/1/3) | synaptic signaling | LCP1, HECW1, PCSK1, NRXN3, NMNAT2 |
FPbrown | 40.9 (3/3/3) | translation, RNA catabolism | ATP5A1, RPS5, SUB1, DNAJC19, RPS8 |
IFGblue | 37.5 (2/3/4) | oligodendrocyte development, myelination | ZDHHC9, PLEKHH1, PCBP4, PLEKHG3, AIG1 |
PHGblue | 40.0 (9/9/4) | translation, RNA catabolism | NUDT21, RAB11A, RPL7, ADAT2, RACK1 |
STGyellow | 36.0 (3/4/2) | myelination, gliogenesis | SCRIB, KIF13B, RDX |
CBEblue | 35.4 (8/6/3) | Golgi vesicle transport, tRNA processing | GNAI1, MFN1, IBTK, ICA1, PCNX2 |
IFGbrown | 35.1 (8/7/5) | learning or memory, synaptic vesicle cycle | DHRS11, JPH3, GUCY1B3, HIPK1, SAMD12 |
TCXbrown | 31.6 (1/4/1) | protein folding | SPR, DHRS11, FKBP4, TASP1, HSPH1 |
CBEbrown | 28.6 (0/3/1) | oligodendrocyte development, myelination | MAN2A1, TMEM63A, ANLN, KIF5B |
TCXblue | 23.5 (1/1/2) | morphogenesis | SPON1, MSI2, NDRG2, YAP1 |
