Fig. 2: Microglia-mediated neuroprotection through TREM2.
A β plaques bind to and interact with microglia TREM2, leading to activation of microglia response, increased phagocytosis, and inhibition of neuroinflammation. Moreover, TREM2 promotes ApoE3 uptake thus exerting additional neuroprotective effects. Nonetheless, TREM2 variants are closely linked with increased AD susceptibility.
