Fig. 7: Butyrate improves gut connectivity and motility in SAMP8 mice. | Molecular Psychiatry

Fig. 7: Butyrate improves gut connectivity and motility in SAMP8 mice.

From: The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse model

Fig. 7: Butyrate improves gut connectivity and motility in SAMP8 mice.

a,b, Quantification of EphB2, synaptophysin (a) and PGP9.5 (b) proteins in colon of Ctrl and SAMP8 mice treated with butyrate (+) or water. Two-way ANOVA and Tukey’s multiple comparisons (n = 5–6 animals per group). c FPO measured for 2 h of Ctrl and SAMP8 mice treated with butyrate (+) or water. Two-way ANOVA and Tukey’s multiple comparisons (n = 14–15 mice per group). (d—g), NOR (d), Y-Maze (e), EPM (f) and OF (g) tests of Ctrl and SAMP8 mice treated with butyrate (+) or not. NOR, discrimination index differences were assessed with paired t-tests. Discrimination index of 0.5 indicates chance preference; Y-Maze, EPM and OF, Two-way ANOVA and Tukey’s multiple comparisons (n = 8–15 mice per group).

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