Fig. 3: Chemogenetic activation of thalamus alters oscillatory coherence. | Molecular Psychiatry

Fig. 3: Chemogenetic activation of thalamus alters oscillatory coherence.

From: Hyperactivation of distinct thalamic nuclei differentially impairs sleep physiology in rats

Fig. 3: Chemogenetic activation of thalamus alters oscillatory coherence.

A, H, O, V Examples of the EEG signal during wake and NREM after injection of vehicle or DCZ of MDT-hM3Dq, VPT-hM3Dq, WMT-hM3Dq and control rats, respectively. Imaginary coherence-frequency plots for pairs of brain areas (frontal cortex, parietal cortex, MDT, VPT and VMT): B–G Plots for MDT-hM3Dq animals (ZT0 to ZT5), (I–N) plots for VPT-hM3Dq animals (ZT0 to ZT3), (P–U) plots for VMT-hM3Dq animals (ZT0 to ZT5), and (W, X) plots for no virus control animals (ZT0 - ZT5). Vehicle (blue), DCZ 0.1 mg/kg (red); N = 12 MDT-hM3Dq rats; N = 9 VPT-hM3Dq rats; N = 10 VMT-hM3Dq rats; N = 12 no virus controls rats. Statistically significant clusters (p < 0.05) are indicated as bars on top based on a paired cluster-based permutation test.

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