Fig. 2: Relationship of altered brain activity in panic disorder with chemoarchitecture and gene expression.
From: Beyond fear circuits: multiscale neurobiological architecture of panic disorder
a, b, Meta-analytically derived increased brain activity (a) was spatially related to distribution of 5-HT1A, SERT, D2, and DAT (* p < 0.05, family-wise error corrected) (b). The color bar represents TFCE-values as weighted sums of the entire local clustered signal on the unthresholded brain map. A multiple linear regression model was fit between expression profiles of candidate genes in panic disorder and the meta-analytic brain pattern), indicating that all genes had explanatory power (R2 = 0.341). Dominance analysis was applied to the independent variables (mRNA expression data) to determine which genes were contributing most to the model fit. Percent contribution is shown in the pie char (c).
