Fig. 6 | Mucosal Immunology

Fig. 6

From: Goblet cell associated antigen passages are inhibited during Salmonella typhimurium infection to prevent pathogen dissemination and limit responses to dietary antigens

Fig. 6

Overriding GAP inhibition results in increased dissemination, worsened colitis, and reduced survival independent of alterations in luminal Salmonella burden. a Representative hematoxylin- and eosin-stained colon sections, b Kaplan–Meier survival curves, c histological scores, d serum cytokine concentrations, e CFUs in colon-draining MLNs, and f luminal Salmonella burden in untreated C57BL/6 mice, streptomycin-pretreated C57BL/6 mice, mice lacking EGFR in GCs (EGFRf/f Math1PR*Cre), mice lacking MyD88 in GCs (MyD88f/f Math1P*RCre), and floxed littermate controls infected with 5 × 107 CFU of Salmonella. Mice in a and c–f were analyzed 6 days following infection; n = 5 or more mice, *p < 0.05. Data presented as ±SEM. Scale bar = 100 µm

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