Fig. 4 | Mucosal Immunology

Fig. 4

From: Herpes simplex virus-binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition

Fig. 4The alternative text for this image may have been generated using AI.

Ab-mediated trapping of HSV-1 as a function of microbial Community State Type (CST). Samples were sequenced with 16 s rRNA whole-genome sequencing analysis and classified into CSTs depending on the predominant microbial species, according to the following groups: Class I (L.crispatus, n = 18), Class II (L.gasseri, n = 4), Class III (L.iners, n = 22), Class IV (G.vaginalis, n = 16), or Class V (L.Jensenii, n = 6).23 After classification, HSV-1 mobility was compared for each Ab condition. a Ensemble-averaged <Deff> in CVM treated with different Ab and b percent fast-moving viruses (Deff) ≥ 0.347 µm2/s. Two-Way ANOVA with multiple comparisons (Tukey’s Multiple Comparison’s Test) (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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