Fig. 1
From: Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury
Dsg2 and Dsc2 are the major cadherins expressed in the intestine and the generated DSG2-deficient animals (DSG2ΔIEC) display an intestine-specific Dsg2 loss. a, b Expression levels of DSG2, DSC2 as well as the other desmoglein and desmocollin family members were assessed by real time RT-PCR in the indicated mouse organs (n = 4–5). c DSG2 mRNA expression was quantified in the highlighted mouse organs of DSG2ΔIEC (ΔIEC) and DSG2fl/fl (fl/fl) mice (n = 4) by real time RT-PCR. Colonic desmoglein 2 (Dsg2) protein levels were assessed in both groups by immunoblotting (n = 5). L7 (mouse ribosomal protein) gene and β-tubulin (βTub) were used as an internal and a loading control, respectively. Dsg, desmoglein; Dsc, desmocollin; Liv, liver; B. duct, common bile duct; G.bl, gallbladder; Kid, kidney; Stom, stomach; Duo, duodenum; Jeju, jejunum; Ile, ileum; Col, colon. Two-tailed Student’s t test was used for statistical analyses. **p < 0.01, ***p < 0.001
