Fig. 5
From: Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis
Effect of NecroX-7 on inflammation in mice with oral mucositis. a Representative immunohistochemical staining for nuclear factor-κB (NF-κB) subunit p65 in the tongue on day 10. Original magnification, ×400. b Quantification of the nuclear NF-κB subunit p65 in a. c Tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-1β expression levels in tongue tissues were determined by real-time polymerase chain reaction using β-actin for normalization. d Serum TNF-α, IL-1β, MIP-1β, IL-18, granulocyte-macrophage colony-stimulating factor (GM-CSF), and vascular endothelial growth factor-A (VEGF-A) levels were measured by enzyme-linked immunosorbent assay on day 10. N7 NecroX-7. *P < 0.05, ***P < 0.001
