Fig. 7

Schematic model illustrating the molecular mechanism of PAFR signaling during epithelial wound repair. Our working hypothesis is that in response to wounding TNFα/IFNγ signaling increases expression of PAFR. Binding of PAF leads to PAFR stimulation which causes Src phosphorylation and ADAM10 activation, inducing cleavage of EGFR ligands, such as HB-EGF, and EGFR activation. Stimulation of EGFR further enhances phosphorylation of Src, which subsequently activates Rac1 via GEFs, increasing ROS accumulation and phosphorylation of FAK. In parallel, Src activation induces FAK phosphorylation to further promote turnover of focal adhesion complexes leading to modulation of cellular migration