Fig. 8

IRF5^Δmye mice demonstrate less effective clearance of oral S. Typhimurium infection. a–c IRF5^WT or IRF5^Δmye mice (2–2.5 months of age) were orally inoculated with S. Typhimurium and assessed 5 days later. a Intestinal permeability by FITC-dextran (n = 5). b Commensal bacterial DNA in Peyer’s patches and MLN (n = 5). c S. Typhimurium CFU in feces (n = 5). d BMMs from IRF5^WT or IRF5^Δmye mice were co-cultured with S. Typhimurium-GFP, gentamycin was added 20 min later, and intracellular S. Typhimurium was then assessed over the next 4 h by flow cytometry (4 replicates; representative of 3 independent experiments). Mean + SEM. Significance is compared to WT mice for each respective condition. *p < 0.05; **p < 0.01