Fig. 2

VI-16 reduced colon damage in DSS-induced colitis mice. a H&E stains of serial sections of colons in DSS-induced colitis mice following VI-16 treatment. b Colon histological damage score and clinical evaluation in DSS-induced colitis mice. c MPO activities in the colonic tissues were detected. d Sections of colon tissues were immunostained with DAPI (blue) and anti CD11b-FITC (green) and observed by confocal laser-scanning microscope. Results are presented as images of colon tissues (left) and quantification of CD11b⁺ cells (right). Representative images are shown. Scale bars, 100 µm. Data are presented as mean ± SD. ^**P < 0.01 compared with normal group; ^#P < 0.05, ^##P < 0.01 compared with DSS group