Fig. 4 | Mucosal Immunology

Fig. 4

From: Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress

Fig. 4

Nlrp3 in hematopoetic cells is critical for protection against DSS-induced injury by VI-16. a Body weight changes of each group (n = 6 per group) were recorded in DSS-treated wild-type and NLRP3−/− mice following 80 mg/kg VI-16 treatment. b The length of colons from each group of mice were measured. c H&E stains of serial sections of colons induced by DSS in wild-type and NLRP3−/− mice following 80 mg/kg VI-16 treatment. d–f Bone marrow chimeras were generated with wild-type (WT) and NLRP3−/− mice. Mice (n = 6 per group) were treated with 3% DSS for 7 days, followed by regular drinking water for 3 days. d Body weight changes, e colon length, and f histopathological changes in colon tissue were examined. Data are presented as mean ± SD. *P < 0.05, **P < 0.01

Back to article page