Fig. 3
From: IL-22-binding protein exacerbates influenza, bacterial super-infection
IL-22BP deficiency decreases inflammation. C57BL/6 and IL-22BP−/− mice were infected with 100 PFU of influenza A/PR/8/34 or vehicle for 6 days prior to infection with 5 × 107 CFU MRSA for 24 h or 104 CFU/mL S. pneumoniae for 48 h. a, b Total cell count in BAL fluid (n = 6–10). c, d Differential cell counts in BAL fluid (n = 6–10). e Protein production of pro-inflammatory cytokines in lung homogenate measured by Lincoplex (n = 4–6). *p < 0.05 Significance was tested by unpaired t-test or one-way ANOVA. Each experiment was independently performed twice and the data shown are from combined experiments
