Fig. 2
From: Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease
Increased production of IL-13Rα2 protein following DSS administration is partially dependent on TNFα and IL-17A in vivo. a Wild-type mice were administered 5% DSS drinking water or normal drinking water for 7 days. On day 7, mice were euthanized and IL-13Rα2 protein levels were measured in the b colon homogenates and c serum by ELISA. d Wild-type mice were given 5% DSS drinking water or normal drinking water for 7 days. During the induction period of DSS-colitis, groups of mice were administered two intraperitoneal injections (250 μg/mouse) of IgG1 isotype control (MOPC-21), anti-TNFα (XT22.11), anti-IL-17A (17F3), or anti-TNFα (XT22.11)/anti-IL-17A (17F3) antibodies. On day 7, mice were euthanized and IL-13Rα2 protein levels were measured in the e colon homogenates and f serum by ELISA. Experimental results are displayed showing the geometric mean. Statistical significance was determined by Student’s t test (b, c) or one-way ANOVA (e, f), where **p < 0.01, **p < 0.001, and ****p < 0.0001. Data are pooled from two independent experiments. (b, c, n = 4–10 mice/group; e, f, n = 10 mice/group)
