Fig. 3
From: Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease
Il13ra2−/− mice are modestly protected from the induction of acute DSS-induced colitis. a Wild-type and Il13ra2−/− mice were administered normal drinking water or 5% DSS drinking water for 7 days. b The body weights of all mice were monitored daily. After 7 days of DSS administration, c the physical appearance was scored prior to euthanizing mice and harvesting colons. d The colon lengths were measured and e the average percent reduction in colon lengths of DSS treated mice over normal drinking water controls were calculated. Distal colon was embedded in paraffin, sectioned, and f stained with H&E and the pathology was scored. Colon homogenates were generated and protein concentrations of g IL-17A, h IL-1β, and i IFNγ were measured by multiplex assay. Experimental results are displayed as the geometric mean except (d) is represented as the mean ± S.E.M. Statistical significance was determined by one-way ANOVA, where *p < 0.05, **p < 0.01, and ****p < 0.0001. Data are pooled from two independent experiments (b–i, n = 10–20 mice per group)
