Fig. 7
From: Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease
Recovery from acute DSS-induced colitis is mediated by IL-13. Wild-type mice were administered 5% DSS drinking water or normal drinking water for days. Then all mice were placed on normal drinking water for a 7-day recovery period. a On days 7 and 11, mice were administered 250 μg/mouse of anti-IL-13Rα2, anti-IL-13Rα2/anti-IL-13, or IgG1 isotype control. b Body weights of mice were recorded daily throughout the induction and recovery periods. Mice were euthanized on day 14 and c colons were harvested and the lengths were measured. d The average percent reduction in colon length were calculated. Distal colons were stained with e H&E and the pathology was f scored. Experimental results are represented as the geometric mean. Statistical significance was determined by one-way ANOVA, where *p < 0.05, **p < 0.01, and ****p < 0.0001. Data are pooled from two independent experiments (n = 5–10 mice per group)
