Fig. 5 | Mucosal Immunology

Fig. 5

From: Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice

Fig. 5

Differences in CD4 and CD8 T-cell recognition of Mtb-infected macrophages. a Lung cells obtained from Mtb-infected C57BL/6 mice and the CD4 (left) and CD8 (right) T-cell recognition of Mtb-infected macrophages or the 300 peptide megapool (p300) was compared by ICS. Combined data from two independent experiments (identified by open or closed symbols), each with five mice/group, analyzed 4 wpi. b The frequency of pulmonary CD4 and CD8 T cells that produced IFN-γ after culture with Mtb-infected macrophages as determined by ICS. The MOI was varied and the actual MOIs are shown. Data are representative of two independent experiments using T cells from five individual mice at 4 WPI or 22 WPI (shown, a, b), analyzed in single replicates. The statistical test was a two-way ANOVA with Tukey’s post-test; actual p values are shown

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