Fig. 6: Inflammatory cell numbers in the bronchoalveolar lavage fluid of air or cigarette smoke-exposed WT mice treated with a miR-155 inhibitor or scrambled control.
From: The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD
Measurement by flow cytometry of total BAL cells (a), macrophages (b), neutrophils (c), dendritic cells (d), CD4+ T lymphocytes (e) and CD8+ T lymphocytes (f) and measurement by ELISA of CCL2 (g) in the bronchoalveolar lavage fluid of WT mice exposed to air or cigarette smoke for 4 weeks and intranasally instilled two times a week with a LNA-modified miR-155 inhibitor or scrambled control (n = 7–8 animals/group). Mmu-miR-155 levels measured by RT-qPCR in lung tissue of C57BL/6 mice exposed to air or cigarette smoke for 4 weeks and treated two times a week with an LNA-modified miR-155 inhibitor or scrambled control (n = 6–7 animals/group) (h). Data are analyzed with the Kruskal–Wallis and Mann-Whitney U test and expressed as mean ± SEM (*P < 0.05, **P < 0.01, ***P < 0.001).
