Fig. 4: Levels of hypo-sialylated T-antigen glycans correlate with levels of total HIV DNA in the ileum of HIV+ ART-suppressed individuals. | Mucosal Immunology

Fig. 4: Levels of hypo-sialylated T-antigen glycans correlate with levels of total HIV DNA in the ileum of HIV+ ART-suppressed individuals.

From: Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection

Fig. 4

a Levels of total HIV DNA measured in the ileum, right colon, and sigmoid colon of HIV+ ART-suppressed individuals, using qPCR without a pre-amplification step. b Levels of integrated HIV DNA measured using qPCR after a pre-amplification step. c Levels of 2-LTR HIV DNA measured using qPCR after a pre-amplification step. The numbers in brackets show the total number of samples positive/total number of samples tested. Lines and error bars represent mean and SEM. Open circles represent limit of detection in samples with undetectable levels of HIV DNA. d Correlation between levels of total HIV DNA, measured in the ileum without a preamplification step, and levels of integrated HIV DNA, measured in the ileum after a preamplification step. Correlation was evaluated using Spearman’s rank correlation coefficient test. e Levels of hypo-sialylated T-antigen glycans correlate with levels of HIV DNA in the ileum. Correlation was evaluated using Spearman’s rank correlation coefficient test.

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