Fig. 5: LP CD4+ T cells produce cytotoxic granules after stimulation.
From: CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile
Representative flow-cytometric dot plots a, b and compiled data c for the intracellular expression of granzyme-B and perforin in LP CD103− and CD103+ CD4+ T cell subsets without and after stimulation with anti-CD3/CD28 beads for 21 h. Red lines indicate median values. Student’s t-test was applied to compare the expression of cytotoxic mediators by both subsets (black horizontal lines), and by unstimulated versus 21 h stimulated cells (red vertical lines and asterisks). **P ≤ 0.01; ns, not significant.
