Fig. 6: Deficiency of Adam15 in CD8+ T cells is crucial for driving the exaggerated lung inflammation and destruction detected in CS-exposed Adam15−/− mice. | Mucosal Immunology

Fig. 6: Deficiency of Adam15 in CD8+ T cells is crucial for driving the exaggerated lung inflammation and destruction detected in CS-exposed Adam15−/− mice.

From: A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice

Fig. 6

Adult WT mice, Adam15−/− mice, Cd8−/− mice, and Adam15−/− × Cd8−/− compound mutant mice were exposed to air or CS 6 days-a-week for 3 months or 6 months. Absolute numbers of all leukocytes (a), macrophages (b), and lymphocytes (c) were counted in bronchoalveolar lavage (BAL) samples. Data are mean ± SEM; n = 7–17 mice exposed to air for 3 months air and 6–11 mice exposed to CS for 3 months. Data were analyzed using a one-way ANOVA followed by pair-wise testing with two-tailed Student’s t tests. *P < 0.05 versus the group indicated. D: alveolar chord length was measured on lung sections as a measure of airspace enlargement. Data are mean ± SEM; n = 5–11 mice exposed to air for 6 months and 10–16 mice exposed to CS for 6 months. Data were analyzed using a one-way ANOVA followed by pair-wise testing with two-tailed Student’s t tests. *P < 0.05 versus the group indicated.

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