Fig. 6: IgG1-ASCs and IgG2-ASCs are the major isotypes of plasma cells substituting for IgA-ASCs in IgA-deficient human patients.

a Representative microscopic images of colonic sections of IgA-sufficient and IgA-deficient patients immunohistochemically stained for IgA⁺, IgM⁺, and IgG⁺ plasma cells. The sections were H&E counter-stained. b Numbers of IgA⁺, IgM⁺, and IgG⁺ plasma cells per representative high-power imaging field (HPF) of colonic sections of IgA-sufficient and IgA-deficient patients. One dot represents one patient sample. c Representative microscopic images of colonic sections of IgA-deficient patients immunohistochemically stained for IgG1⁺, IgG2⁺, IgG3⁺, and IgG4⁺ plasma cells. The sections were H&E counter-stained. d Numbers of IgG1⁺, IgG2⁺, IgG3⁺, and IgG4⁺ plasma cells per representative high-power imaging field of colonic sections of IgA-deficient patients. One dot represents one patient sample. e Representative microscopic images of colonic sections of IgA-sufficient and IgA-deficient patients immunohistochemically stained for CCR10⁺ plasma cells. The sections were H&E counter-stained.