Fig. 5: Disease phenotype and changes in microbiota observed in β7-deficient IL-10−/− mice are recapitulated by IgA deficiency. | Mucosal Immunology

Fig. 5: Disease phenotype and changes in microbiota observed in β7-deficient IL-10−/− mice are recapitulated by IgA deficiency.

From: Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis

Fig. 5

a Weights, rectal temperatures, and b percent survival of indicated strains by 10 weeks of age. c Colon and cecum histological indices of disease severity of indicated genotypes at 8–12 weeks of age. d Fecal bacterial counts from indicated strains determined via RT-qPCR for 16S rRNA expression. e Fecal bacterial alpha diversity (Shannon’s index) and f beta diversity principal coordinate analysis of the indicated mouse groups. g Relative abundance of bacterial taxa at the class level in feces of the indicated mouse strains. All data are presented as mean ± S.D, from n > 10 mice in each dataset. Each data point represents an individual mouse. Statistical significance determined using one-way ANOVA, followed by Sidak’s multiple comparison test.

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