Table 2 Single-cell omics studies of adaptive immune cells in the small intestine and blood of adult healthy individuals and patients with celiac disease.
Reference | Sample | Donors | Target population | Staining of CeD-relevant antigen-specific cells | Technology |
|---|---|---|---|---|---|
Healthy gut | Â | Â | Â | Â | Â |
Nair et al.123 | Proximal jejunum resections and/or peripheral blood | Controls | B-lineage cells | No | Mass cytometry |
Celiac disease | Â | Â | Â | Â | Â |
Atlasy et al.129 (preprint) | Mucosal duodenal biopsies (Lamina propria and epithelium) | CeD patients Controls | Immune cells | No | scRNA-seq |
Lindeman et al.71 | Mucosal duodenal biopsies (Lamina propria) | UCeD patients TCeD patients Controls | Plasma cells | Yes | scRNA-seq (Smart-seq2) |
Han et al.77 | Peripheral blood or mucosal duodenal biopsies | UCeD patients CeD patients on gluten challenge Controls | T cells | No | Mass cytometry |
van Unen et al.121 | Mucosal duodenal biopsies and/or peripheral blood | UCeD patients TCeD patients RCDII patients EATLII patient Controls | Immune cells | No | Mass cytometry |
Christophersen et al.122 | Mucosal duodenal biopsies and/or peripheral blood | UCeD patients TCeD patients CeD patients on gluten challenge SSc patients SLE patients Influenza patients Controls | T cells | Yes | Mass cytometry |
