Fig. 1: Overview of three main recognised Treg subsets and their potential role in immunity.
From: The fellowship of regulatory and tissue-resident memory cells
Three main types of Treg cells are recognised, type 1 displaying features in common with Th1, such as the transcription factor Tbet and the chemokine receptor CXCR3. Type 3 Treg cells share a transcriptional programme with Th17 cells, such as expression of RORγt and CCR6. Each Treg subset can modulate respective immune responses (red lines). Type 2 Treg cells are characterised by expression of GATA3 and ST2 amongst others. There is limited data if this subset is involved in modulating type 2 immunity. ST2 may have a role in stabilising effector Treg cells and in tissue repair and homeostasis. In addition, type 1 and 3 Treg cells may express ST2 and may potentially show a convergence with type 2 Treg cells (dashed lines) and provide a similar role in tissue repair (green arrows).
