Table 2 Association between gray matter volume in the bilateral putamen and severity of symptoms

From: A transdiagnostic neuroanatomical signature of psychiatric illness

 

Right putamen

Left putamen

Diagnosis

Coordinates

Partial correlation

Coordinates

Partial correlation

All patients

29 9 −8

r = 0.313, p < 0.001

−29 8 −5

r = 0.326, p < 0.001

FEP

28 7 8

r = 0.072, p = 0.731

−27 8 6

r = 0.178, p = 0.042

MDD

26 12 −8

r = 0.240, p = 0.023

−26 10 −5

r = 0.101, p = 0.512

PTSD

32 5 −9

r = 0.247, p = 0.020

−27 9 −8

r = 0.210, p = 0.050

OCD

24 11 0

r = 0.275, p = 0.009

−24 11 1

r = 0.253, p = 0.017

  1. Symptoms were measured using PANSS total score for FEP; HAM-D score for MDD; CAPS score for PTSD; and Y-BOCS total score for OCD patients. The reported results refers to partial correlations, where age and gender were controlled in the correlation between GM and disease severity.
  2. FEP first-episode psychosis, MDD major depressive disorder, PTSD post-traumatic stress disorder, OCD obsessive-compulsive disorder