Table 1 Nested R² results for all individual studies for each gene set

From: The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia

Study details			Gene sets
Study ID	Case (N)	Control (N)	TCF4	FMRP	MIR137 (up)	MIR137 (down)	CHD8 (up)	CHD8 (down)	Cancer	Heart disease
clm2	3426	4085	0.00400	0.00132	0.00266	0.00034	0.00046	0.00000	0.00470	0.00130
mgs2	2638	2482	0.00840	0.00741	0.00534	0.00596	0.00469	0.00415	0.00401	0.00515
clo3	2105	1975	0.01693	0.01226	0.01090	0.01455	0.01039	0.04791	0.01627	0.00143
s234	1980	2274	0.00584	0.00232	0.00207	0.00084	0.00258	0.00113	0.00053	0.00179
swe5	1764	2581	0.00636	0.00761	0.00618	0.00397	0.00498	0.00379	0.00333	0.00325
irwt	1291	1006	0.00980	0.01104	0.00764	0.00005	0.00312	0.01148	0.01386	0.00609
gras	1067	1169	0.00820	0.00433	0.00765	0.00230	0.00407	0.00965	0.00044	0.00246
swe6	975	1145	0.00970	0.00366	0.02518	0.00414	0.00202	0.00305	0.00175	0.00221
ajsz	894	1594	0.00434	0.00592	0.00172	0.00850	0.00249	0.00154	0.00227	0.00001
aber	719	697	0.00623	0.00832	0.00314	0.00093	0.00171	0.01189	0.00026	0.00070
ucla	700	607	0.00835	0.00573	0.00251	0.00266	0.00005	0.00174	0.00007	0.00327
uktr	649	649	0.00911	0.00047	0.03779	0.03675	0.00208	0.00358	0.00690	0.00031
pewb	574	1812	0.00603	0.00211	0.00317	0.00158	0.00100	0.00565	0.00686	0.00108
cou3	530	678	0.00725	0.00817	0.01952	0.00010	0.00551	0.00599	0.00131	0.00455
lemu	516	516	0.00011	0.00023	0.00017	0.00935	0.00013	0.00001	0.00182	0.00425
uclo	509	485	0.00528	0.01287	0.00618	0.01092	0.00459	0.00105	0.00000	0.00158
lie5	497	389	0.00912	0.00144	0.00028	0.00018	0.00125	0.00495	0.00101	0.00638
denm	471	456	0.00068	0.01327	0.00062	0.00025	0.00001	0.00010	0.00220	0.00312
asrb	456	287	0.00402	0.00187	0.00745	0.00503	0.00061	0.00010	0.00183	0.00249
munc	421	312	0.00558	0.01080	0.00006	0.00737	0.00234	0.00158	0.00397	0.00134
cati	397	203	0.01392	0.01451	0.02506	0.00855	0.00108	0.02120	0.00005	0.00137
caws	396	284	0.00268	0.00539	0.00722	0.00231	0.00011	0.00994	0.00153	0.00613
top8	377	403	0.00772	0.01392	0.00601	0.00016	0.00024	0.00394	0.00003	0.00363
edin	367	284	0.00528	0.04107	0.00202	0.01422	0.00085	0.01435	0.00378	0.00280
port	346	215	0.00016	0.00135	0.00185	0.00487	0.00000	0.00586	0.00038	0.00021
umeb	341	577	0.00684	0.00864	0.00409	0.01769	0.00659	0.00752	0.00195	0.00122
msaf	325	139	0.00026	0.00064	0.00169	0.00080	0.00009	0.00335	0.00158	0.00009
ersw	265	319	0.00635	0.00846	0.00327	0.00351	0.00085	0.00003	0.00015	0.00675
dubl	264	839	0.00921	0.00025	0.00434	0.00224	0.00141	0.01166	0.02123	0.00845
egcu	234	1152	0.00291	0.00213	0.00041	0.00047	0.00449	0.00037	0.00520	0.00027
swe1	215	210	0.00133	0.00027	0.00237	0.00326	0.00221	0.03613	0.00243	0.01048
buls	195	608	0.00579	0.00950	0.01389	0.00028	0.00979	0.00280	0.00821	0.00119
umes	193	704	0.01759	0.00096	0.00041	0.00078	0.00084	0.00155	0.00026	0.00156
zhh1	190	190	0.00023	0.00111	0.01705	0.00005	0.00063	0.00041	0.00031	0.00195
lacw	157	245	0.02095	0.02732	0.00884	0.01177	0.02024	0.01505	0.00536	0.00354
pews	150	236	0.00076	0.00004	0.00038	0.01161	0.00008	0.00192	0.00126	0.00095
lie2	133	269	0.00948	0.00167	0.01504	0.00286	0.01548	0.00407	0.00096	0.00015
butr	70	70	0.00577	0.00397	0.00210	0.00075	0.00495	0.00218	0.00251	0.00005
cims	67	65	0.00005	0.00006	0.00602	0.00830	0.02008	0.00455	0.00226	0.00164

Table of results in each individual study; the first column indicates the PGC2 label used for each study. The table is sorted by the number of cases. Highlighted boxes had a level of significance p < 0.05. Further details for each study and their respective size can also be found in the supplement and the original PGC2 study [1]

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Table 1 Nested R² results for all individual studies for each gene set

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