Fig. 3

Differential transcript expression (DTE) analysis of CC samples from lithium-treated and untreated rats. The volcano plots depict the fold changes and p-values for all analyzed transcripts based on expression quantification with a RSEM and b Salmon. Significant differentially expressed transcripts (FDR < 0.05) are colored in red. c Venn diagram of significant DE transcripts as determined with RSEM and Salmon quantification, respectively. The intersection represents the number of transcripts (n = 487) that were identified as DE with both tools. d The 487 DE transcripts commonly identified with RSEM and Salmon quantification had highly correlated fold changes (r = 0.987) in terms of both the magnitude and direction of effect. RSEM: RNA-seq by expectation maximization