Fig. 4

Expression of lithium-associated eQTL genes in human brain samples. a Venn diagram showing the number of BD-associated eQTL genes identified using each of the three gene expression databases Braineac, GTEx, and CMC. Intersections show the number of eQTL genes shared between databases. No single eQTL gene was identified by all three databases. 11 of the 12 genes that were both lithium-associated DE genes (Lit-DEG) and BD-associated eQTL genes were identified only by Braineac, while one gene was identified by both Braineac and CMC. b Bar plots depicting the expression levels of RPS23 and GRIN2A in human CC samples (left) and rat CC samples (right). The error bars show the standard errors for the mean relative expressions. eQTL: expression quantitative trait locus, Braineac: the brain eQTL Almanac, GTEx: genotype-tissue expression, CMC: The CommonMind Consortium, Lit: lithium, DEG: differentially expressed gene, CTRL: healthy human control subjects, BD: bipolar disorder, CC: Corpus callosum