Table 2 Linear regression models for hippocampal BOLD (arbitrary units) and volume (mm3).

From: Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity

  

HC BOLD (a.u.)

HC volume (mm3)

Model

SNPs

β

95% CI

P

β

95% CI

P

APOE + ɛ4

2

−0.064

−0.251

0.123

0.501

0.022

−0.132

0.176

0.776

pT_5 × 10−8

21

−0.032

−0.113

0.048

0.431

−0.041

−0.110

0.027

0.237

pT_0.001

737

0.013

−0.070

0.096

0.757

−0.054

−0.124

0.016

0.133

pT_0.005

2642

0.071

−0.011

0.153

0.088

−0.086

−0.156

−0.016

0.016

pT_0.01

4747

0.057

−0.026

0.140

0.178

−0.082

−0.152

−0.012

0.022

pT_0.05

17,297

0.073

−0.012

0.159

0.091

−0.032

−0.103

0.039

0.377

pT_0.1

29,718

0.073

−0.010

0.157

0.086

−0.004

−0.074

0.065

0.902

pT_0.2

49,658

0.092

0.009

0.175

0.029

−0.001

−0.071

0.070

0.987

pT_0.5

91,417

0.102

0.019

0.186

0.016

−0.012

−0.082

0.057

0.727

pT_1

133,305

0.104

0.020

0.187

0.015

−0.012

−0.082

0.057

0.725

  1. Standardised beta reflects adjusted beta coefficients (controlling for genetic and demographic confounds) and 95% confidence intervals for each estimate. AD-PRS = Alzheimer’s disease polygenic risk score. ɛ4+ indicates the presence of an APOE ɛ4 allele. HC BOLD (a.u.) regressions also controlling for HC volume
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