Table 1 Receiver Operating Characteristic (ROC) curves and sensitivity analyses for the classification of patients into antipsychotic responders and non-responders using the simplified index of FDOPA uptake (SUVRc) and the gold standard (Kicer) index of dopamine synthesis capacity in the striatum and associative striatal subdivision for Dataset1 and Dataset2.

From: A potential biomarker for treatment stratification in psychosis: evaluation of an [18F] FDOPA PET imaging approach

 

AUC ROC

Sensitivity at 100% specificity cut-off

Whole striatum

Associative

Whole striatum

Associative

Dataset1

Dataset2

Dataset1

Dataset2

Dataset1 (%)

Dataset2 (%)

Dataset1 (%)

Dataset2 (%)

SUVRc 60 min

0.70*

0.86*

0.74*

0.83*

31

79

31

64

SUVRc 75 min

0.77*

0.87*

0.80*

0.85*

39

79

46

64

SUVRc 90 min

0.66NS

0.81*

0.74*

0.81*

23

43

23

36

Kicer

0.83*

0.74*

0.87*

0.75*

46

50

61

50

  1. The p value tests the null hypothesis that the area under the curve really equals 0.50 (chance).
  2. AUC area under the curve.
  3. *p < 0.05; NS p > 0.05.
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