Table 2 An overview of the linear mixed model results for the neurophysiology, metabolite, vital sign, and the profile of mood states (POMS) data.
Variable | Mean (±SE) | Fixed effect | Low vs. placebo | High vs. placebo | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Placebo | Low dose | High dose | F | P | T | P | Lower 95% CI | Upper 95% CI | T | P | Lower 95% CI | Upper 95% CI | ||
40 Hz ASSR | Power* | 0.34 (±0.11) | 0.43 (±0.11) | 0.59 (±1.1) | 5.26 | 0.01 | 1.23 | 0.22 | −0.17 | 0.73 | 3.21 | <0.001 | 0.28 | 1.18 |
ITPC* | 0.18 (±0.02) | 0.22 (±0.02) | 0.2 (±0.02) | 3.10 | 0.05 | 1.82 | 0.07 | 0.00 | 0.10 | 2.38 | 0.02 | 0.01 | 0.12 | |
30 Hz ASSR | Power | 0.46 (±0.08) | 0.64 (±0.08) | 0.42 (±0.08) | 0.09 | 0.91 | 0.42 | 0.67 | −0.36 | 0.56 | 0.30 | 0.77 | −0.39 | 0.53 |
ITPC | 0.104 (±0.002) | 0.105 (±0.002) | 0.108 (±0.002) | 4.34 | 0.02 | −0.77 | 0.44 | −0.02 | 0.01 | 2.07 | 0.04 | 0.00 | 0.03 | |
20 Hz ASSR | Power* | 0.62 (±0.07) | 0.42 (±0.07) | 0.61 (±0.07) | 3.07 | 0.05 | −1.87 | 0.06 | −0.58 | 0.02 | 0.45 | 0.65 | −0.23 | 0.37 |
ITPC | 0.14 (±0.005) | 0.15 (±0.005) | 0.14 (±0.005) | 2.02 | 0.14 | 0.10 | 0.92 | −0.02 | 0.02 | 1.79 | 0.08 | 0.00 | 0.04 | |
Resting | Power* | −50.61 (±0.48) | −50.89 (±0.47) | −50.45 (±0.47) | 5.14 | 0.01 | 1.18 | 0.24 | −1.21 | 4.77 | −1.98 | 0.05 | −5.98 | 0.01 |
Slope | −0.97 (±0.06) | −1.04 (±0.07) | −0.92 (±0.07) | 1.78 | 0.17 | −1.76 | 0.08 | −0.55 | 0.03 | −0.28 | 0.78 | −0.33 | 0.25 | |
KP metabolites | 3-HAA* | 3.35 (±0.73) | 4.33 (±0.74) | 6.38 (±0.74) | 8.63 | <0.001 | 1.47 | 0.15 | −0.66 | 4.46 | 4.10 | <0.001 | 2.75 | 7.86 |
Kynurenic acid* | 6.05 (±1.54) | 8.8 (±1.55) | 10.5 (±1.55) | 3.56 | 0.03 | 1.86 | 0.06 | −0.23 | 7.94 | 2.58 | 0.01 | 1.24 | 9.38 | |
Kynurenine | 296.93 (±27.61) | 335.1 (±27.76) | 322.08 (±27.72) | 2.30 | 0.10 | 1.88 | 0.06 | −3.45 | 130.00 | 0.03 | 0.98 | −65.77 | 67.54 | |
Quinolinic acid | 47.05 (±3.39) | 50.25 (±3.36) | 51.84 (±3.35) | 2.92 | 0.06 | 2.35 | 0.02 | 1.87 | 21.74 | 0.69 | 0.49 | −6.48 | 13.35 | |
AV-101 metabolites | 4-CL-3-HAA* | 3.8 (±2.95) | 12.8 (±3.03) | 19.59 (±3.04) | 6.14 | 0.00 | 1.54 | 0.13 | −3.52 | 27.92 | 3.50 | 0.00 | 12.13 | 43.68 |
7-CL-KYNA* | 2.4 (±27.83) | 90.88 (±28.41) | 168.38 (±26.47) | 3.33 | 0.04 | 1.70 | 0.09 | −19.33 | 258.00 | 2.53 | 0.01 | 38.56 | 315.71 | |
4-CL-KYN* | 228.94 (±1988.1) | 18092.86 (±2029.32) | 26628.56 (±2064.37) | 20.34 | <0.001 | 5.60 | <0.001 | 21925.04 | 45880.60 | 5.42 | <0.001 | 20966.67 | 45070.22 | |
POMS | Total | 11.59 (±1.65) | 12.03 (±1.65) | 11.58 (±1.65) | 1.74 | 0.18 | −1.80 | 0.07 | −5.34 | 0.24 | −1.31 | 0.19 | −4.65 | 0.93 |
Elation total | 3.61 (±0.58) | 3.77 (±0.58) | 3.63 (±0.58) | 2.35 | 0.10 | −2.17 | 0.03 | −3.69 | −0.17 | −1.15 | 0.25 | −2.78 | 0.73 | |
Vitals | Pulse* | 68.84 (±1.82) | 70.52 (±1.81) | 69.91 (±1.82) | 8.54 | <0.001 | 3.61 | 0.00 | 2.63 | 8.91 | 3.54 | 0.00 | 2.54 | 8.88 |
Diastolic pressure* | 80.79 (±2.35) | 78.96 (±2.35) | 76.37 (±2.35) | 3.62 | 0.03 | −1.08 | 0.28 | −4.11 | 1.19 | −2.67 | 0.01 | −6.28 | −0.96 | |
Systolic pressure | 122.52 (±2.69) | 119.64 (±2.69) | 120.14 (±2.7) | 0.10 | 0.91 | −0.43 | 0.67 | −3.67 | 2.36 | −0.12 | 0.90 | −3.22 | 2.84 | |
