Fig. 4: Central FAAH inhibition reversed colitis-induced anxiety-like behavior. | Neuropsychopharmacology

Fig. 4: Central FAAH inhibition reversed colitis-induced anxiety-like behavior.

From: Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase

Fig. 4

We examined (A) time in the open arms and found main effects of colitis reducing open arm time, and PF administration increasing it. Planned comparisons revealed that there was a reduction in open arm time between the vehicle saline vs. TNBS groups. TNBS animals treated with 1 μg PF had significantly increased open arm time relative to vehicle treated animals. Colitis reduced (C) open arm entries and (G) head dips, but there was no effect of FAAH inhibition or interaction between colitis and PF on these measures. For (B) closed arm time, (D) closed arm entries, (E) total arm entries and (F) open arm latency there was not a significant effect of colitis, FAAH inhibition or interaction between PF and TNBS. H Macroscopic tissue damage was increased with colitis, but this was modulated by PF administration, specifically, with the 1 µg dose, which had reduced damage scores compared to the TNBS vehicle group. n = 12–24/group. *p < 0.05, ****p < 0.0001. saline vs. TNBS within same treatment, ♦♦ p < 0.01 vs. vehicle of same condition. Saline = left, black bars with circles. TNBS = right, orange bars with squares.

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