Table 2 Meta-analysis results for all drugs combined.

From: Opioid antagonists are associated with a reduction in the symptoms of schizophrenia: a meta-analysis of controlled trials

Weighting

Model

G

P

k

CI

I2

P (I2)

All Scales

Unweighted

Standard

0.263

0.0266

22

0.034–0.493

0.799

<0.0001

 

Bootstrap

0.262

0.0002

30

0.118–0.516

–

–

Weighted

Standard

0.288

0.0266

22

0.034–0.493

0.799

<0.0001

 

Bootstrap

0.283

<0.0001

30

0.140–0.602

–

–

Total Scales

Unweighted

Standard

0.135

0.1198

14

−0.040–0.311

0.421

0.0490

 

Bootstrap

0.193

0.0155

19

0.0468–0.351

–

–

Weighted

Standard

0.135

0.1198

14

−0.040–0.311

0.421

0.0490

 

Bootstrap

0.192

0.0197

19

0.0361–0.356

–

–

All Positive Scales Combined

Unweighted

Standard

0.338

0.0158

17

0.073–0.604

0.813

<0.0001

 

Bootstrap

0.328

<0.0001

21

0.159–0.656

–

–

Weighted

Standard

0.373

0.0158

17

0.073–0.604

0.814

<0.0001

Bootstrap

0.362

<0.0001

21

0.192–0.782

–

–

All Negative Scales Combined

Unweighted

Standard

–

–

–

–

–

–

 

Bootstrap

0.667

0.1388

6

−0.185–2.217

–

–

Weighted

Standard

–

–

–

–

–

–

 

Bootstrap

0.711

0.1185

6

−0.124–2.217

–

–

Hallucinations

Unweighted

Standard

0.468

0.0934

9

−0.099–1.035

0.918

<0.0001

 

Bootstrap

0.391

0.0091

14

0.098–0.985

–

–

Weighted

Standard

0.574

0.0934

9

−0.099–1.035

0.920

<0.0001

 

Bootstrap

0.454

0.0031

14

0.134–1.163

–

–

Delusions

Unweighted

Standard

–

–

–

–

–

–

 

Bootstrap

0.728

<0.0001

7

0.169–2.031

–

–

Weighted

Standard

–

–

–

–

–

–

 

Bootstrap

0.844

<0.0001

7

0.214–2.031

–

–

Total Positive Scales

Unweighted

Standard

0.442

0.0840

8

−0.077–0.962

0.879

<0.0001

 

Bootstrap

0.442

<0.0001

8

0.142–1.195

–

–

Weighted

Standard

0.469

0.0840

8

−0.077–0.962

0.949

<0.0001

 

Bootstrap

0.469

<0.0001

8

0.138–1.384

–

–

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