Fig. 5: Junk-food does not alter CP-AMPARs expression or function in female rats.

a Experiment timeline. b Average GluA1 surface expression was not affected by junk-food in obesity-prone (OP) or obesity-resistant (OR) female rats. c Average GluA2 surface expression was not affected by junk-food in obesity-prone or obesity-resistant female rats. d Normalized amplitude before and after Naspm (200 µM): Naspm decreases relative amplitude in both obesity-prone female rats fed a chow and junk-food groups. Inset: example eEPSC from chow and junk-food obesity-prone female groups before (black) and after Naspm (red). e No differences in Naspm sensitivity were found between obesity-prone chow vs. junk-food groups. g Average AMPA/NMDA ratio was enhanced in obesity-prone females fed a junk-food diet compared with obesity-prone females fed a chow diet. h NMDAR amplitude was similar between obesity-prone females fed a chow diet and a junk-food diet. i AMPAR amplitude was similar between obesity-prone females fed a chow diet and a junk-food diet. j Representative traces of AMPAR-mediated (black) and NMDAR-mediated (red) currents.