Fig. 1: Graphs show differences in global topological properties between patients with bipolar disorder and health controls at different time points.

The clustering coefficient (Cp) (p = 0.009) and characteristic path length (Lp) (p = 0.04) were significantly different between the two groups at the baseline. Increased Cp was still significantly different (p = 0.045) after 1 week’s treatment. An asterisk designates network metrics with a significant difference (p < 0.05).