Fig. 1: BI 409306 dose–response study in adult CON or MIA offspring (Study 1). | Neuropsychopharmacology

Fig. 1: BI 409306 dose–response study in adult CON or MIA offspring (Study 1).

From: Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders

Fig. 1

(A) Effects of vehicle or drug exposure on social interaction, as indexed by the social preference index. (B) Effects of vehicle or drug exposure on PPI. (C) Effects of vehicle or drug exposure on Amph-induced hyperlocomotion in the open field. All values are means and error bars show the standard error of the mean. N = 8–10 mice per treatment group (POL animals originating from 7 litters, CON animals from 5 litters, respectively, for each treatment group). Data were analyzed using one-way ANOVA (social interaction test) or RM-ANOVA (PPI and Amph-induced hyperlocomotion tests) with post hoc Tukey’s tests. *P < 0.05; **P < 0.01 vs CON—Vehicle. Amph amphetamine, ANOVA analysis of variance, CON offspring of vehicle-treated control mice, MIA offspring of poly(I:C)-treated mice, PPI prepulse inhibition; SAL saline.

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