Fig. 2: Study of add-on BI 409306 in combination with risperidone in adult CON or MIA offspring (Study 2). | Neuropsychopharmacology

Fig. 2: Study of add-on BI 409306 in combination with risperidone in adult CON or MIA offspring (Study 2).

From: Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders

Fig. 2

(A) Effects of vehicle or drug exposure on social interaction, as indexed by the social preference index. (B) Effects of vehicle or drug exposure on PPI. (C) Effects of vehicle or drug exposure on Amph-induced hyperlocomotion in the open field. All values are means and error bars show the standard error of the mean. N = 10–12 mice per sex per treatment group (each male and female animal in the MIA treatment groups is derived from a different litter; total MIA litters: 15, with 10–12 litters per group; CON animals from 5 litters). Data were analyzed using one-way ANOVA (social interaction test) or RM-ANOVA (PPI and Amph-induced hyperlocomotion tests) with post hoc Tukey’s tests. ***P < 0.001 vs CON— Vehicle, $P < 0.05, $$P < 0.01, $$$P < 0.001 vs MIA—Vehicle. Amph amphetamine, ANOVA analysis of variance, CON offspring of vehicle-treated control mice, MIA offspring of poly(I:C)-treated mice, PPI prepulse inhibition, RIS risperidone; SAL saline.

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