Fig. 3: SST-mediated inhibitory dynamic in the PL is moderated by sex and alcohol binge drinking.
From: Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice
A (Left) ChR2-expressing SST neurons in the PL. Scale bar 1 mm. (Right) Photostimulated action potential fidelity in SST neurons upward to 10 Hz. B Representative traces of SST-mediated IPSCs in PL pyramidal neurons in males and females. C Binge drinking did not alter SST-mediated IPSC amplitude in PL pyramidal neurons in either sex. D No differences in SST-evoked IPSC paired pulse ratio on pyramidal neurons across groups and sexes. E Representative traces of SST-mediated IPSCs in PL non-SST, putatively GABAergic neurons in males and females. F Binge drinking enhanced SST-mediated IPSC amplitude onto non-SST neurons in male mice, but not female mice. G Binge drinking reduced SST-mediated IPSC paired pulse ratio in female mice, but not male mice. DID: N = 5 male mice and 5 female mice, control: N = 6 male mice and 4 female mice. *p < 0.05. **p < 0.01. Bonferroni’s post-hoc test.
