Fig. 1: The source of monoamine and cholinergic projections to the primate PFC.

The approximate position of the monoamine and cholinergic cell bodies that project to PFC are shown on a midsagittal image of a human brain. Note that many are localized more laterally, and all project to other cortical areas as well. Ach acetylcholine, nbM nucleus basalis of Meynert, DA DA, SNc/VTA substantia nigra pars compacta and ventral tegmental area, 5HT serotonin, raphe dorsal raphe, NA NA, LC locus coeruleus.