Fig. 7: Effects of the DA D2 receptor agonist on delay activity after distraction in healthy volunteers.

Adapted from Bloemendaal et al. [168] with permission. A Schematic diagram of the delayed match-to-sample working memory task. During the encoding phase, subjects were presented with three face stimuli. After an 11.1 s delay period, they were shown a face or scene distractor. Subjects pressed a right or left button to indicate whether this stimulus matched a pre-learned target face or scene. After another delay period of 11.1 s, the probe stimulus appeared and the subject made a left/right button press to indicate whether this probe stimulus matched one of the encoded stimuli. B Bromocriptine significantly increased the distractor error cost: participants made more errors when the distractor category was congruent with the dimension of the encoding stimuli (i.e., faces vs. scenes). C Data extracted from the dlPFC cluster that exhibits a correlation between bromocriptine-related increases in the distractor cost and bromocriptine-related decreases in delay-period activity after congruent (face) vs. incongruent (scene) distractors. D Locus of correlation between drug effect on behavioral distracter cost and drug effect on neural distracter cost in dlPFC. The bar indicates T values and figures are thresholded for a T value of 3.79, corresponding to a p value of 0.001 uncorrected for multiple comparisons.