Fig. 2: Brain images and time activity curves. | Neuropsychopharmacology

Fig. 2: Brain images and time activity curves.

From: Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [11C]PHNO PET

Fig. 2: Brain images and time activity curves.

a Orthogonal cross-sections of co-registered PET and MR images from a representative participant who received TAK-041 40 mg. For columns from left to right, images are PET1 (baseline), PET2 (post d-AMPH), PET3 (post d-AMPH + TAK-041), and structural (T1-weighted) MRI. PET images are shown as SUV summed from 10 to 90 min; b Time–activity curves and simplified reference tissue model fits (using cerebellum as reference region) for a representative participant (participant 10). AMPH amphetamine, Cer cerebellum, MRI magnetic resonance imaging, PET positron emission tomography, SUV standard uptake value, Pu putamen, ROI region of interest, VSt ventral striatum.

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