Fig. 3: TAK-041 induced attenuation of dopamine release. | Neuropsychopharmacology

Fig. 3: TAK-041 induced attenuation of dopamine release.

From: Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [11C]PHNO PET

Fig. 3: TAK-041 induced attenuation of dopamine release.

a ΔBPND values in the putamen and ventral striatum for all participants; b box-and-whisker plot and individual ΔΔBPND values for putamen and ventral striatum for all participants. d-AMPH d-amphetamine, BPND binding potential relative to the non-displaceable component, PET positron emission tomography, ΔBPND change in BPND post-d-AMPH with positive values indicating reduction in BPND, ΔΔBPND the change in ΔBPND with positive values indicating a reduction in ΔBPND post- d-AMPH + TAK-041 compared to post-d-AMPH alone.

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